GAVI Alliance, September 2011
The GAVI Alliance today announced it will provide funding for 16 more developing countries to introduce rotavirus vaccines and 18 more countries to introduce pneumococcal vaccines -- a major step towards protecting children against severe diarrhoea and pneumonia -- the two leading child killers.
Rotaflash, October 2011
Findings from a study published in the Lancet show that child mortality from rotavirus remains high. Tragically, approximately 95% of rotavirus deaths occurred in countries that are eligible to receive GAVI-support to introduce rotavirus vaccines.
In 2003, vaccines against rotavirus were poised to reach the global market, but surprisingly few people knew the virus’ name, let alone that it was the leading cause of severe diarrheal disease. “We’ve never heard of it,” ministers of health would say when PATH staff members like Evan Simpson began meeting with them to spread the word about the virus and new vaccines against it.
RotaFlash, January 2012
The Phillipines has become the first country in Southeast Asia to implement the World Health Organization's (WHO) recommendation to introduce life-saving rotavirus vaccines through its national immunization program.
One of the tools that will help us defeat diarrheal disease is vaccines – both the rotavirus vaccines that are licensed and the vaccines against bacteria that cause diarrhea that are still in development.
Enterotoxigenic Escherichia coli (ETEC) and Shigella, leading causes of bacterial diarrhea, are among the top five pathogens causing moderate-to-severe diarrhea among children in Africa and South Asia.1 Vaccines to protect against ETEC and Shigella are currently under development.
Infections from Shigella, which causes dysentery, and ETEC are typically caused by contaminated food or water. Illness can lead to dehydration and malnutrition, as well as impaired physical and cognitive development in young children.2 In low-resource countries, where access to medical care is often limited and inappropriate use of antibiotics is strengthening bacterial pathogens, vaccines to prevent ETEC and Shigella hold dramatic potential.3
PATH is collaborating with private- and public-sector partners to advance safe, effective, and affordable vaccines against ETEC and Shigella. We’re pursuing a wide range of approaches to bring at least one vaccine candidate for each pathogen to late-stage development. We have also identified a highly promising vaccine component that we plan to test with several vaccine candidates. Finally, to ensure that ETEC and Shigella vaccines reach all children who need them, we are assessing manufacturing partners, mostly in emerging countries, to take on the eventual manufacture and distribution of these vaccines.
1 Kotloff KL, Nataro JP, Blackwelder WC, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. The Lancet. 2013 [early online publication].
2 Niehaus MD, Moore SR, Patrick PD, et al. Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown. American Journal of Tropical Medicine and Hygiene. 2002;66(5):590–593.
3 Walker RI, Van De Verg LL, Hall RH, Schmitt CK, Woo K, Hale V. Enteric vaccines for pediatric use. Workshop summary. Vaccine. 2005;23(46-47):5432–5439.
Photo: PATH/Amy MacIver
It was just a conference room in Delhi, not the Taj Mahal by any means. No lapis lazuli or other luxuries. (Although many would consider the flush toilets, hot water, and soap in the bathrooms down the hall as luxuries).
Do you remember how your mom took care of you when you got sick?
Moms everywhere want to take care of their kids. Diarrhea can be deadly, but mothers have hope when they have access to simple solutions. Proven, affordable tools should be at-hand for every mom, such as safe water and sanitation, oral rehydration therapy (ORT), zinc, nutrition, breastfeeding, and rotavirus vaccines. Help us spread the word about these solutions so no child has to die from diarrhea.
The 1,000 days between a woman’s pregnancy and her child’s 2nd birthday represent a critical but short window of time to ensure a child’s future health and prosperity. Children who are well-nourished during this critical window reap a lifetime of benefits for themselves and their communities. The nutrition that a mother and her baby receive during these 1,000 days has a profound impact on a child’s ability to grow, learn and rise out of poverty.
Vibe Ghana, February 2012
In April 2012, Ghana will introduce two new vaccines that will protect children against pneumonia, diarrhea, and meningitis.