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submitted by Dr. Richard Walker
09/18/2014 at 12:21

As you might have guessed, hearing good news about declining diarrhea morbidity and mortality rates among children is always exciting news for someone like me. But, I’m also thrilled when donors recognize and support promising new interventions that require a critical financial investment to move them closer to saving young lives.

PATH recently announced a new award from the United Kingdom’s Wellcome Trust, which is funding the development of a unique Shigella vaccine candidate through our enteric vaccine project. Infection with Shigella bacteria, or shigellosis, causes bloody diarrhea and represents a major health threat to children living in poorer countries where access to clean water and appropriate hygiene and sanitation practices to prevent such diseases are lacking. Currently, there is no licensed vaccine available to prevent shigellosis.

Since 2010, our team has been working in partnership with Drs. Bill and Wendy Picking, who were researchers at Oklahoma State University (OSU), to develop a vaccine to prevent the short- and long-term negative effects of shigellosis. Unlike other Shigella vaccines currently under development, the approach used with this candidate, DB Fusion, targets proteins found on the surface of the bacteria to provide broad protection. Since different types of Shigella are found in different parts of the world, a vaccine that targets only one or two of them wouldn’t be ideal for everyone. But, this novel approach may be able to provide the broadest coverage possible across all of the different types of Shigella bacteria with one simple vaccine.

Another exciting thing about the DB Fusion is that it’s intended for administration via a small needle that goes only into the skin’s outermost layer (known as intradermal immunization). Though intradermal immunization is a procedure that has long been in use with other vaccines, this represents one of the first times that it will be tested with a Shigella vaccine candidate.

In collaboration with the Picking team, we completed preclinical research studies demonstrating the DB Fusion’s protection against several types of Shigella, and we are now collaborating on developing a process to manufacture the vaccine for clinical use. With the Wellcome Trust award, we plan to take the DB Fusion a few steps further, conducting early-stage clinical studies on the vaccine’s safety in humans and, if warranted, a subsequent trial to show that it can protect humans against illness caused by Shigella.

As a result, I am truly delighted that the Wellcome Trust recognized the incredible potential that the DB Fusion has to save children’s lives, and that they decided to support us along this exciting journey. 


Photo credit: PATH/Gabe Bienczycki.

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submitted by Hope Randall
09/12/2014 at 11:36

Last year around this time, we had our doubts about whether a toilet calendar concept would fly – or whether it would get flushed down the drain (I know, I know – I can’t help myself).

I remember our graphic designer’s trepidation; a toilet-themed calendar challenges basic preconceptions about aesthetically pleasing visual design principles. Even if we, and our sanitation colleagues, loved the idea, would it translate well to others who aren’t necessarily talking toilets on a daily basis?

The results exceeded our expectations; our printer couldn’t keep up with the demand. Hearing the gleeful giggles of calendar recipients over the toilet-shaped design was like a gift in itself. We received photos from partners and US government officials proudly displaying their personal copies in their respective workplaces. People started asking us about a 2015 edition in August.

The calendar did more than make people smile; it opened the door for holding critical conversations about sanitation in settings where they might not otherwise have occurred. And for us, that was the best part. The decision to hold another call for photos this year was obvious.

The foundation of last year’s success? Your photos! We can’t cause a commode-tion without you. Help us make 2015 another great year for the loo!

Ready to get started? Details here. 

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submitted by Case Keltner
09/10/2014 at 10:17

Originally posted on the WASH Advocates blog

On August 27, 2014, the United States Agency for International Development (USAID) released a Request for Applications (RFA) funding opportunity for its Water, Sanitation, and Hygiene (WASH) for Health Project in Ghana. Aimed at augmenting WASH practices and reducing undernutrition among Ghanaian populations, the RFA provides a structured framework for establishing collaborative global health partnerships between the Government of Ghana, USAID, international NGOs, and community health organizations.  USAID hopes to bolster cross-sectoral collaboration to mitigate the effects of undernutrition and the plethora of negative health outcomesassociated with limited access to WASH.

The RFA represents a crucial step forward in the global fight to end extreme poverty by improving access to vital health education and services, and underscores WASH as a pivotal piece to achieving this objective.

While recent data revealed significant improvements in the water sector, sanitation remains a severely neglected issue in Ghana. The country must make considerable strides in the coming months to reach its Millennium Development Goal (MDG) goal of 54 percent coverage by 2015. USAID’s new RFA proactively addresses this issue by emphasizing the nexus of nutrition, WASH, and public health.

USAID is also putting the Multi-Sectoral Nutrition Strategy into practice by integrating WASH and nutrition efforts through WASH for Health’s collaboration with nutrition programs such as the SPRING Project and Feed the Future to improve nutrition in Ghana. By accentuating the importance cross-sectoral integration and leveraging public/private partnerships, USAID can leverage resources more efficiently to address issues like WASH, maternal and child health, and nutrition. Certain program components, such as the development and distribution of “Essential WASH Actions” and “Essential Nutrition Actions” packages, utilize WASH and nutrition education as a means to curtail correlated illnesses such as diarrheal disease and stunting.  Similarly, USAID’s attempt to amalgamate key elements of projects like the Communicate for Health Project and Systems for Health Project with the new WASH for Health project establishes a precedent for responding to multifaceted health challenges concurrently.

Adequately addressing the interrelated issues of WASH and nutrition requires enhanced collaboration, strong public-private partnerships, and most importantly, ambitious initiative. Through this opportunity, USAID will aim to simultaneously combat undernutrition and improve WASH access and transparency rather than disconnecting these fundamental issues and placing them in separate policy silos. WASH Advocates is optimistic that this RFA will positively impact the lives of Ghanaians who lack access to essential health services.

For more information on this RFA, please visit application submissions must be finalized by September 24, 2014.



Photo credit: (USAID/Kasia McCormick) 2012

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submitted by Dr. John Boslego
09/02/2014 at 12:17

Our work on rotavirus vaccines has brought PATH’s Vaccine Development team to India countless times over the past several years. But rather than research or prepping for clinical studies, this week’s trip brings us to India for a related, yet different undertaking: joining fellow scientists, advocates, and other partners to celebrate progress and share experiences.

Through most of the International Rotavirus Symposium’s 20-plus-years history, the focus has been on the vital potential of rotavirus vaccines. But recent installments, including this year’s event which opens today in New Delhi, are increasingly celebrating the vaccines’ real-world impact. With rotavirus vaccines now introduced in more than 20 of the world’s hardest-hit countries (and counting), families are realizing the benefit of protection against the leading cause of severe and fatal diarrhea. Rotavirus vaccines are truly changing—and saving—lives.

India will soon join this illustrious collection of countries with its pending introduction of ROTAVAC®, an indigenous new vaccine developed through a social innovation partnership that combined the expertise of Indian scientists and international organizations, including PATH. ROTAVAC® holds exciting potential—if scaled to current immunization rates in India, the vaccine could prevent 20,000 child deaths each year and dramatically slash hospitalizations and clinic visits. Not only a lifesaving solution for child health, rotavirus vaccination can also spare the costs associated with illness—a critical boost as low-income, high-burden communities strive to rise above poverty.

The progress highlighted at the International Rotavirus Symposium is made possible only through partnerships and key collaborations. The foundation of PATH’s rotavirus projects—and a pivotal element of successful research and delivery—is our close collaboration with emerging-country governments, advocates, and manufacturers, and we look forward to highlighting these at the symposium. My colleagues in PATH’s Vaccine Development program will present the latest data from our collaborative efforts to develop non-replicating rotavirus vaccine candidates—administered intramuscularly to potentially overcome limitations of oral vaccines in high-burden populations. PATH’s Vaccine Access and Delivery Program will present exciting updates on research to optimize the performance of the current rotavirus vaccines in global use, including alternate administration schedules. Partnerships both within and beyond PATH allow us to contribute to the complete spectrum in developing, evaluating, and delivering safe, effective, and affordable rotavirus vaccines worldwide.

Along this development and delivery continuum, the translation of evidence to advocacy also plays a key role. The ROTA Council, a distinguished group of technical experts, will host an interactive session to highlight the crucial connections between researchers and advocates that ultimately inspire and advance lifesaving change. Evidence delivered through such advocacy can foster national policies that integrate rotavirus vaccines into a comprehensive strategy, giving communities the best possible chance and all tools available to defeat childhood diarrhea.

I extend my congratulations to all involved in unveiling the intricacies of rotavirus vaccines’ performance, discovering and improving new formulations, bringing vaccination to vulnerable families, and incorporating rotavirus vaccines into comprehensive national strategies. To be sure, there is further research on the horizon—from studying new candidates to evaluating the long-term impact of current vaccines—and far more advocacy to undertake. But today is a good reminder that there also is so much to celebrate.



Photo credit: PATH. 

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08/27/2014 at 11:49

Each year, on October 15, over two hundred million people gather together in countries around the world and celebrate Global Handwashing Day. This international day of advocacy and action shines a spotlight on the state of handwashing in each country or community where it is celebrated and helps to raise awareness about the benefits of handwashing.  Why such a big focus on handwashing? This simple action, when practiced regularly can significantly reduce the risk of illness and death from diarrheal disease and pneumonia. With 1.7 million children dying from these causes each year, we certainly think that is a reason to celebrate!

To help individuals and organizations plan Global Handwashing Day celebrations in their community, region, or country, the Global Public-Private Partnership for Handwashing has developed a Planner’s Guide. This year, the Planner’s Guide was updated to reflect the changing nature of Global Handwashing Day celebrations and the corresponding needs of planners.

Based on consultations with partners and others who have utilized the guide, we have attempted to create an updated guide that is action-oriented and provides planners with resources and inspiration to help as they implement a successful Global Handwashing Day celebration, and to encourage handwashing promotion throughout the year.

Those who have used the Planner’s Guide in years past will be familiar with the overall structure of the document; indeed, some sections such as the Five Facts about Handwashing are still very much the same. The biggest changes are found in the hands-on portion of the Guide. Here planners will find a step-by-step guide to planning an event, which is supplemented by fact boxes, event ideas, and tips for success. The annexes feature ideas for celebrations depending on the audience, an event planning checklist, facts about handwashing, and more.

Whether you’ve celebrated Global Handwashing Day for years, or this is your first, we hope that the Planner’s Guide will have provide you with the tools and ideas necessary to make your event a success. Let us know how it goes by uploading pictures and stories to our interactive, online map. And don’t forget, always wash your hands with soap!


Photo credit: Shahbaz Fawbush, MD

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