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submitted by Deborah Kidd
06/30/2014 at 12:42

In two short weeks, my daughter will turn one year old. Looking back at her newborn photos, I wonder how this year went by so quickly. How could that wrinkly creature who could scarcely open her eyes or control her little limbs now be this squawking, nearly walking toddler? A solid and healthy tyke today, she seemed so delicate and breakable back then. It’s no wonder my anxiety ran amok! What if her swaddling covered her mouth while she slept? How could we tell if her skin tinged the slightest bit, threatening jaundice? And how could I politely convince neighbors and friends to slather themselves in antibacterial gel?

I had an online community of mothers and easy access to pediatricians to help me keep my girl safe and healthy. In places where new parenthood is fraught with far greater threats, the recent Every Newborn Action Plan aims to bring the same security. Issued by a partnership that includes UNICEF and the World Health Organization, and boosted by supportive evidence published in The Lancet, the action plan calls for a renewed commitment to dramatically improve the health and survival of newborn babies and their mothers. Coupled with the global commitment to safeguard the fragile health of all children under five years old through the 2012 Promise Renewed pledge, this new plan completes a circle of protection for the most vulnerable among us.

While plans like these center on inspiring action among policymakers and donors, they are supplemented by tools that communities and families can implement today to increase children’s chances at a healthy start. Chief among these early interventions is breastfeeding, which gets to work straightaway to help develop infants’ immune systems, improving responses to vaccines and preventing infections including pneumonia and diarrhea.

Another powerful tool at a mother’s disposal is her voice. One of the most striking statements in The Lancet’s summary of its Every Newborn article series notes that the most affected communities can often be “the most vocal agents for change.” Not all mothers have a platform like this very blog to share news, encourage healthy behaviors, and call for national commitments to their families’ health. But a key component of the Every Newborn plan aims to empower and engage parents. I am proud to lend my voice to raise awareness about the urgent needs for health equity and the opportunity for all mothers and fathers to rely on a safe start for their children. And I hope to raise a daughter who one day adds her voice to this global community as well.

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submitted by Heather Ignatius
06/23/2014 at 14:35

Heather Ignatius, Senior Policy and Advocacy Officer for PATH, is the proud mom of 3 year old Cleo and 7 month old Lily.

 

Every night when I put my three-year-old daughter to sleep I ask her, “what are you thankful for?” I’m trying to teach her the concept of gratitude and it’s nice to have the last thoughts before going to bed each evening be about the people, privileges or experiences that we are grateful for.  I try and mix it up each night to capture how truly blessed we are to have so much. 

When I ask Cleo this question, her response is always an immediate, “You first, mama,” and it gives me pause for a moment while I try to come up with something new to say.  Because, you see, if I answered that question honestly, the answer would be the same. Every. Single. Night.  I’m thankful that my girls are alive, happy and healthy. 

In my job at PATH, I’m an advocate for global child and maternal health, so I’m constantly reminded about what I have that other mothers around the world do not.  I won’t have to carry my feverish child in my arms for miles to the nearest clinic in hopes of getting treatment in time. My kids have had their rotavirus and pneumococcal vaccines, making it unlikely that they will perish from two of the leading killers of kids.  My decision to breastfeed had more to do with IQ points and bonding – not survival.   My girls will more than likely make it to see their fifth birthdays.

Mothers in other countries are not so lucky.  Each year we lose 6 million kids to diseases like diarrheal disease and pneumonia and 800 moms a day die giving birth.  Tragically, these deaths are completely preventable.  

But there is reason for optimism. Over the last 20 years, the number of child deaths has been halved and maternal deaths have reduced by one third as programs to save moms and babies have expanded. These programs teach families the importance of healthy behaviors like breastfeeding and handwashing; they provide essential services such as having trained healthcare workers present at births; and they scale up low cost health products such as medicines for life threatening childhood diseases and vaccines to prevent them. 

In 2012 governments around the world came together to acknowledge that we had reached a turning point in maternal and child survival.  The United States, Ethiopia and India issued a call to action to put an end to preventable child and maternal deaths within a generation. It was a pivotal moment—the first time governments set a radically ambitious goal for child and maternal health and pledged action to meet it.   

Reaching this goal is possible if we scale up the interventions we know work. And we can reach it even faster with new innovations – products like a low cost breathing device for newborn asphyxia or new screening devices to test for common ailments and risks during pregnancy.

As the second anniversary of this call to action approaches, commitment abounds. More than 175 countries around the world have signed onto the pledge to end preventable child and maternal deaths.  Yet we are at a critical moment where ambition must turn into action in short order.  Now is the time for governments to put forward the strategies and resources to achieve the goal. 

This month two social media campaigns are being launched to call attention to child and maternal health: Mom and Baby and 5th Birthday and Beyond.  Share your photos and help show the world how precious these lives are.  But more importantly, call upon your government to follow through on the commitment it has made to end preventable child and maternal deaths.  

Ps. If you want to know what Cleo is thankful for, most nights she says ”candy!”

 

-- Heather Ignatius is a Senior Policy and Advocacy Officer for PATH and proud mom of 3 year old Cleo and 7 month old Lily.

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submitted by Aristide A. Djenda
06/19/2014 at 09:27

Mothers wait to vaccinate their babies at the Kpele-Eleme Health Centre in Togo.

 

My cousin Mada, who lives in Atakpamé, Togo (about 160 km from the capital Lomé), tragically lost her son Dissirama to severe diarrhea. After the baby fell ill, my cousin took him to a traditional healer who prepared a potion and told my cousin to pour it on her ancestors’ graves and ask for their blessing to spare her son’s life. The traditional healer did not advise my cousin to give her son oral rehydration salts (ORS) or to take him to the hospital to receive intravenous fluids, which are necessary to treat severe dehydration from diarrhea. Because Dissirama did not receive ORS or intravenous fluids, he passed away.

Consultation of traditional healers is deeply rooted in Togo’s culture, especially in rural areas. While traditional healers may play important roles in Togolese society, children suffering from severe diarrhea need to be treated with ORS or intravenous fluids. Sadly, parents and caregivers in rural areas often lack access to information about the importance of taking children to health centers for medical treatment. In addition, health centers are often located far away from rural communities and may be out of reach of parents and caregivers.

I am the chair of the Union of Nongovernmental Organizations (NGOs) in Togo (UONGTO), a national umbrella organization of NGOs that works to strengthen advocacy and communication capacities of Togolese NGOs. UONGTO is a member of the GAVI Civil Society Organisation (CSO) Constituency Steering Committee and the focal point for the GAVI-funded CSO Platform that promotes immunization in Togo. CSOs such as UONGTO are vital in the efforts to educate rural communities about proper medical treatment of diseases and to mobilize and motivate parents to get their children vaccinated to prevent disease. CSOs also work to encourage policymakers to financially support the introduction of new vaccines and to strengthen existing health systems.

In 2009, with funding from GAVI, UONGTO conducted a census of maternal and child health CSOs in Togo to increase CSO engagement in promoting routine immunization. This effort earned us a prize at the 2009 GAVI Alliance Partners' Forum. With this momentum, UONGTO raised funds to train CSOs in advocacy and community mobilization. In 2011, with the support of the World Health Organization, our CSO platform wrote to the Ministry of Health asking the Government to submit an application to GAVI for support to introduce pneumococcal and rotavirus vaccines.  

Today, three years after our CSO platform wrote to the MoH, Togo finally celebrates the historic dual introduction of pneumococcal and rotavirus vaccines! These new vaccines prevent the most severe forms of pneumonia and diarrhea - killer diseases devastating our children. Pneumonia causes 16% of deaths of Togolese children under five and diarrhea causes another 10%. With the introduction of these lifesaving vaccines, Togo’s government and CSOs have an opportunity to work in partnership to help our communities by providing the knowledge and tools to prevent and treat these diseases. Going forward, CSOs in Togo will aim to increase outreach to rural communities with important health information, including news that these lifesaving vaccines are available free of charge.  That is why today is a day of glory for Togo!

I thank my Government for taking this critical step, because the introduction of these vaccines will permit Togo to significantly reduce childhood diseases and deaths linked to pneumonia and diarrhea. I hope my Government will use today’s introductions as a catalyst to increase communication efforts in rural communities to help them understand that vaccination is the best way to prevent the most severe forms of these diseases. I also thank donors and the GAVI Alliance for their financial support, which enables Togo to continue our efforts to achieve the Millennium Development Goals.

Parents and caregivers, when children are suffering from severe illness, it is important to take them to health centers for treatment. This way, we can avoid we can avoid unnecessary deaths like that of my little cousin Dissirama. It is even better to prevent disease in the first place through vaccination, so please go to your nearest health center where these lifesaving vaccines are now available! Protect your children against deadly diseases like diarrhea and pneumonia! Vaccinate your children and save their lives!

Ewé : Misi abͻta na miabéviwo, élé djͻwoanu éyé élaԃéwo da tso dͻsi wuaméwo gbͻ

Kabyè: Biya hεtu kεnε pͻyͻ kãtu bilisuwεkudomiε sim sinisi dε

[To vaccinate your children is to save. Protect them against deadly diseases.]

Photo credit: TOMETY Mawli-Dodi

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submitted by Marvin Meyers, PhD
06/18/2014 at 09:34

A few months ago, PATH's Drug Development blog provided an overview of the drug discovery and development process. What is very clear is that, while drug discovery is a very difficult and risky business, the potential benefit for millions of people worldwide makes it all worthwhile. Large pharmaceutical companies have significant resources to help absorb the failures that are inevitable in the drug discovery business. As nonprofit groups working to discover new drugs for diseases in developing countries, we need to do everything in our power to minimize the risk for failure and improve the likelihood for success. This requires partnering between groups that have complementary expertise and resources.

 

Moving beyond the lab bench

CWHM at Saint Louis University is a relatively new player in the rapidly expanding “academic drug discovery center” phenomenon. Formed in 2010, CWHM is made up of a group of drug discovery scientists with more than 200 years of collective experience in the pharmaceutical industry. This group is essentially a complete drug discovery project team embedded in an academic environment, with expertise in translation of basic science into new drug candidates for clinical trials.

This model of a drug discovery team in an academic environment takes advantage of CWHM’s expertise in drug discovery—that is, the teamwork and scientific proficiency needed to successfully identify a potential new drug. However, to be truly successful, CWHM needed collaborators that have expertise in 1) the broad spectrum of diseases that directly affect people in low-resource settings and 2) the design and execution of clinical trials. This is why partnering with PATH through its Drug Development program is critical to the successful identification of a new antidiarrheal drug. PATH has the expertise in both diarrheal diseases and implementation of clinical trials for potential new antidiarrheal drugs.

 

Targeting diarrheal disease

In 2010, CWHM initiated a project that sought to reposition high-quality inhibitors of neutral endopeptidase (NEP) that had previously failed to reduce blood pressure in clinical trials, yet were demonstrated to be safe for humans. We established preclinical models of diarrhea and began investigating NEP inhibitors for antidiarrheal effect in those models.

Early on, we partnered with PATH’s Drug Development program to advance this project. Our collaboration was instrumental in guiding our efforts at a very early stage, and helped to focus our efforts in a manner that kept the need for a clinically relevant agent at the forefront of our thoughts. After working together for a little over two years, we have now identified three high-quality clinical compounds that have demonstrated antidiarrheal effects in preclinical models.

 

Maximizing impact

What has contributed to our success is teamwork. We discuss results and strategy monthly with our drug development colleagues at PATH. This ensures that our efforts are aligned with the common goal: to identify an excellent treatment for acute secretory diarrhea that will be widely available and convenient for those who need it so that it becomes a drug that will be used to save lives.

The best way to prevent needless deaths from diarrhea in developing countries is through a team effort that combines the strengths of each partner. As we continue our partnership with PATH, we are eager to see what other successes we can achieve together.

 

More information

 

·         PATH receives grant to expand drug research for deadly diarrhea

·         Grant to PATH will fund research at SLU’s Center for World Health and Medicine

·         PATH’s Drug Development program

 

Photo credit: Jonathan Torgovnik ©

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submitted by Ayo Ajayi
06/16/2014 at 09:27

Schoolchildren in Zambia pair health and hygiene through lessons in sanitation. The country is pursuing an integrated strategy to overcome childhood diarrheal disease with education, proven interventions, and new tools. Photo: PATH/Gareth Bentley.

 

Dr. Ayo Ajayi is PATH’s vice president of International Development.This post originally appeared on The Guardian‘s Global Development Professionals Network partner zone.

 

When a child is educated, a community can prosper. On the International Day of the African Child, commemorated on June 16 each year, we celebrate school enrollment and educational improvements. But when a child is not healthy, he cannot attend school. If he is vulnerable to resilient diseases that target poor, rural communities, he may not even reach school age.

Each year, we celebrate the growing number of African children who thrive beyond their first years, young lives spared from preventable diseases. Often, we can credit innovation: new tools that help conquer old threats. The African Rotavirus Symposium, which begins this week, will celebrate rotavirus vaccines’ steady march across the continent—expanding access to an innovative tool to conquer the most common and deadly cause of childhood diarrhea.
 

Pairing innovations to tackle dangerous diseases

Just as a child’s health and education are inextricably linked, the integration of proven stalwarts with innovative new tools can yield lifesaving symmetry when tackling the most dangerous childhood diseases. Pairing access to new vaccines with established interventions like proper sanitation and oral rehydration therapy gives us the best chance to overcome childhood diarrhea.

Rotavirus vaccines, education on nutrition and hygiene, and the availability of clean water are some of the interventions that have helped slash childhood diarrhea deaths by half since 2000. But more than 1,500 children still lose their lives each day to the life-threatening dehydration that diarrhea can cause.
 

Diarrheal disease wages war on Africa's children

In the poor, rural communities where diarrhea poses its greatest threat, malnutrition and opportunistic coinfections strip away children’s ability to withstand diarrheal disease or slow down their recovery from it. As a clinician in Nigeria many years ago, I remember often struggling to find veins to administer IV fluids in children who were severely dehydrated and wasting away from malnutrition. Their brothers and sisters waited nearby—uninfected at the moment, but just as malnourished, just as vulnerable—and I knew it would only be a matter of time before their family visited the hospital once again.

Today, it is heartening to travel to large cities throughout Africa and see far fewer children fighting diarrheal disease. But beyond the busy streets and bustling capitals, diarrheal disease still wages its war on Africa’s children.
 

We have the solutions

Though diarrheal disease is stubborn and often intractable, it is not insurmountable. Even in the world’s poorest places, deaths among children are declining. We have the tools and we know what works. Putting them into action takes a strategic combination of partnership, resources, and political will.

In this collaborative and comprehensive spirit, my organization, PATH, is working with partners worldwide, at local levels, and across our own disciplines to advise national policies; increase access to new interventions; bring clean, safe water to rural communities; research new medicines; and more.

But action also requires awareness. Raising our voices together, we can encourage an integrated approach to diarrheal disease, and a brighter future for Africa’s children.

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